Study of visual analogue scale of nasal symptoms between chronic rhinosinusitis patients and doctors / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To investigate the difference of the symptoms evaluation between CRS patients and doctors.@*METHOD@#Seven symptoms including nasal obstruction, watery rhinorrhea, sneezing, rhinocnesmus, itching of eyes, hyposmia and facial pain were evaluated by visual analog scales (VAS) by the patients. The assigned rhinologist finished VAS evaluation of doctor based on the patient's description of their symptoms. Rank test was used to analyze the difference for each VAS scores of symptom between patients and doctor. Spearman test was used to analyze the effect of age in VAS scores and the effect of gender was analyzed by using Mann-Whitney test.@*RESULT@#We found that the sum and every single patient's nasal symptoms VAS scores both showed statistical significantly difference (t = 4.51 P 0.05) also, gender of patients didn't show statistical significant (P > 0.05).@*CONCLUSION@#There were differences between patient's and doctor's nasal symptoms VAS scores and the VAS scores of patients were higher than the doctor's. Age and gender of patient were not related to the VAS evaluation.

Association study between single nucleotide polymorphism in AOAH gene and chronic rhinosinusitis in a Chinese population / 中华耳鼻咽喉头颈外科杂志

<p><b>OBJECTIVE</b>To replicate the polymorphisms in risk genes of chronic rhinosinusitis in a Chinese Han population.</p><p><b>METHODS</b>Enrolled in this study were CRS patients with nasal polyps (n = 306, CRSwNP), CRS patients without nasal polyps (n = 332, CRSsNP), and controls (n = 315) in a Chinese population. All the patients were recruited from clinic of the department of Otorhinolaryngology of Beijing Tongren Hospital between 2008 February and 2009 July. A total of 10 single nucleotide polymorphisms (SNPs) selected from previous identified SNPs associated with CRS in Canadian population were individually genotyped. Allele and genotype frequencies were calculated by frequency counting, the chi-square test or exact method were applied to analyze the results.Final results were corrected by Bonferroni multiple correction.SPSS 13.0 software was used for statistical analysis.</p><p><b>RESULTS</b>One SNP in AOAH gene(rs4504543, P = 1.95 × 10⁻⁵, OR = 0.559 0) was identified to be significantly associated with whole CRS cohort. After subgroup analysis for the presence of nasal polyps (CRSwNP and CRSsNP), the same SNP in AOAH (rs4504543, P = 3.47 × 10⁻¹², OR = 0.284 8) was also found to be significantly associated with CRSsNP cohorts.</p><p><b>CONCLUSIONS</b>AOAH was significantly associated with CRS and its polymorphisms might play a role in the susceptibility to develop CRS in Chinese population.</p>

The relationship between serum interleukins and T-lymphocyte subsets in patients with severe acute respiratory syndrome / 中华医学杂志(英文版)

<p><b>OBJECTIVES</b>To observe the changes of serum interleukins (IL), T-lymphocyte subsets, and white blood cell (WBC) count in patients with severe acute respiratory syndrome (SARS), and to investigate the relationship between injured immune function, immune response and disturbed immune adjustment in SARS patients.</p><p><b>METHODS</b>The levels of serum IL-2, IL-10, IL-12 and T-lymphocyte subset counts were measured in 35 clinically diagnosed SARS patients by using enzyme linked immunosorbant assay (ELISA). The relationship between the measured results and WBC count was further analyzed.</p><p><b>RESULTS</b>The level of serum IL was increased to a great extent in the 35 SARS patients, and the levels of serum IL-2, IL-10 and IL-12 were 242.53 (92.69) pg/ml, 77.43 (63.37) pg/ml and 65.94 (43.21) pg/ml, respectively. The level of serum IL-2 increased markedly (P < 0.01). The peripheral blood CD(3)(+), CD(4)(+) and CD(8)(+) counts were lower than normal in 23 patients (67.7%), 26 patients (74.3%) and 15 patients (42.9%), respectively. The peripheral blood WBC counts were lower than 4.0 x 10(9)/L in 10 patients, and their CD(3)(+), CD(4)(+) and CD(8)(+) counts were 583.90 (315.58) x 10(6)/L, 272.00 (94.13) x 10(6)/L and 209.00 (72.21) x 10(6)/L, respectively. The peripheral blood WBC counts were (4.0 - 10.0) x 10(9)/L in 20 patients, and their CD(3)(+), CD(4)(+) and CD(8)(+) counts were 700.00 (502.96) x 10(6)/L, 347.00 (247.58) x 10(6)/L and 322.05 (228.47) x 10(6)/L, respectively. The peripheral blood WBC counts were higher than 10.0 x 10(9)/L in 5 patients, and their CD(3)(+), CD(4)(+) and CD(8)(+) counts were 1466.00 (630.86) x 10(6)/L, 783.00 (311.14) x 10(6)/L and 640.00 (294.40) x 10(6)/L, respectively. The decreased CD(3)(+), CD(4)(+) and CD(8)(+) counts were consistent with the decreased WBC counts. The level of IL in SARS patients was significantly higher than that in patients with chronic hepatitis B (P < 0.01).</p><p><b>CONCLUSIONS</b>The level of serum IL is closely related to cell immunity in SARS patients. The level of serum IL is increased evidently while CD(3)(+), CD(4)(+) and CD(8)(+) counts decrease. Both serum IL and CD are associated with injury of immune function, and thus they could be regarded as a monitoring index for judging the condition of SARS patients and prescribing immune therapy.</p>